Building on the pioneering work by Dr Don Lalonde, both Dr Asif Ilyas and Dr James Clarkson’s research has focused on advancing our understanding of wide awake surgery’s outcomes and safety, be it an office setting or in an ambulatory surgical center. The result of these efforts, as well as that of other surgeon researchers, is the establishment of the high efficacy, safety, and cost effectiveness of wide awake surgery in the US.
National guidelines for Wide Awake Office Based Surgery
Dr Clarkson published a detailed evidenced-based analysis of wide awake office based surgery and collated the evidence on its safety and efficacy, while also establishing guidelines for office based surgery.
- Schank KJ, Engwall AJ, Kuhns BW, Oakes TC, Bray SM, Clarkson JHW. Guidelines for Wide-Awake Local Anesthesia Surgery with No Tourniquet in the Office Setting Using Field Preparation Sterility. Plast Reconstr Surg. 2023 Feb 1;151(2):267e-273e. doi: 10.1097/PRS.0000000000009850. Epub 2022 Nov 10. PMID: 36696323.
Safety of Wide Awake Surgery
Many studies have focused on the safety of wide awake surgery, consistently confirming its safety – particularly with the use of epinephrine in the hand. Both Dr Lalonde and Dr Ilyas separately published their series of consecutive 3,110 and 4,054 patients, respectively, and confirmed no epinephrine-related complications
- Lalonde D, Bell M, Benoit P, Sparkes G, Denkler K, Chang P. A multicenter prospective study of 3,110 consecutive cases of elective epinephrine use in the fingers and hand: the Dalhousie Project clinical phase. J Hand Surg Am. 2005;30(5):1061-1067. PMID:16182068
- Ilyas AM, Jennings JD, Banner L, Matzon JL. Wide-Awake Surgery With Local Anesthesia and Epinephrine Is Safe. Orthopedics. 2020 Nov 1;43(6):e529-e532. doi: 10.3928/01477447-20200827-03. Epub 2020 Sep 3. PMID: 32882049.
Infection Rates in Wide Awake Surgery
Examination of infection rates following surgery is a common and important area of analysis. Relative to wide awake surgery, separate studies by Drs Clarkson, Ilyas, and others has established that there is no increased infection rate when surgery is done in the office versus an operating and whether preoperative antibiotics are used or not.
- Oakes TC, Wong KC, Schank KJ, Haan P, Bray SM, Clarkson JHW. Infection Rate Comparison during Transition from Hospital to Office WALANT Enabled by Virtual Reality. Plast Reconstr Surg Glob Open. 2022 May 13;10(5):e4285. doi: 10.1097/GOX.0000000000004285. PMID: 35702540; PMCID: PMC9187176.
- Kistler JM, Munn M, McEntee R, Ilyas AM. Antibiotic Prophylaxis in Clean Hand Surgery: A Prospective Cohort Analysis of Major and Minor Complications. J Hand Surg Glob Online. 2023 Apr 21;5(4):421-425. doi: 10.1016/j.jhsg.2023.03.011. PMID: 37521558; PMCID: PMC10382872.
- McKnight KN, Smith VJS, MacFadden LN, Chong ACM, Van Demark RE Jr. Wide-Awake Hand Surgery Has Its Benefits: A Study of 1,011 Patients. J Hand Surg Glob Online. 2022 Jun 17;4(6):394-398. doi: 10.1016/j.jhsg.2022.05.008. PMID: 36425372; PMCID: PMC9678697.
Patient Perceptions & Outcomes in Wide Awake Surgery
Perhaps the most important evidence is how a patient feels and does after undergoing wide awake surgery. Study after study has confirmed both the strong patient perception and outcomes supporting the use of wide awake surgery.
- McKnight KN, Smith VJS, MacFadden LN, Chong ACM, Van Demark RE Jr. Wide-Awake Hand Surgery Has Its Benefits: A Study of 1,011 Patients. J Hand Surg Glob Online. 2022 Jun 17;4(6):394-398. doi: 10.1016/j.jhsg.2022.05.008. PMID: 36425372; PMCID: PMC9678697.
- Hoxhallari E, Behr IJ, Bradshaw JS, Morkos MS, Haan PS, Schaefer MC, Clarkson JHW. Virtual Reality Improves the Patient Experience during Wide-Awake Local Anesthesia No Tourniquet Hand Surgery: A Single-Blind, Randomized, Prospective Study. Plast Reconstr Surg. 2019 Aug;144(2):408-414. doi: 10.1097/PRS.0000000000005831. PMID: 31348351.
- Tulipan JE, Kim N, Abboudi J, Jones C, Liss F, Kirkpatrick W, Rivlin M, Wang ML, Matzon J, Ilyas AM. Open Carpal Tunnel Release Outcomes: Performed Wide Awake versus with Sedation. J Hand Microsurg. 2017 Aug;9(2):74-79. doi: 10.1055/s-0037-1603200. Epub 2017 May 22. PMID: 28867906; PMCID: PMC5579466.
- Lalonde D, Martin A. Tumescent local anesthesia for hand surgery: improved results, cost effectiveness, and wide-awake patient satisfaction. Arch Plast Surg. 2014 Jul;41(4):312-6. doi: 10.5999/aps.2014.41.4.312. Epub 2014 Jul 15. PMID: 25075350; PMCID: PMC4113687.
Davison PG, Cobb T, Lalonde DH. The patient’s perspective on carpal tunnel surgery related to the type of anesthesia: a prospective cohort study. Hand (N Y). 2013;8(1):47-53. https://doi.org/10.1007/s11552-012-9474-5 PMID:24426892
Pain & Anxiety in Wide Awake Surgery
In recent years awareness around opioid-sparing pain management and mitigating anxiety for patients undergoing surgery has become forefront to optimize the patient experience and safety. Both Dr Clarkson and Dr Ilyas have carefully examined this issue and put forth strategies that improve upon the surgical experience relative to pain and anxiety highlighting how surgery can actually provide a better patient surgical experience.
- Miller MB, Gabel SA, Gluf-Magar LC, Haan PS, Lin JC, Clarkson JHW. Virtual Reality Improves Patient Experience and Anxiety During In-office Carpal Tunnel Release. Plast Reconstr Surg Glob Open. 2022 Jul 13;10(7):e4426. doi: 10.1097/GOX.0000000000004426. PMID: 35919690; PMCID: PMC9278931.
- Townsend CB, Bravo D, Jones C, Matzon JL, Ilyas AM. Noise-Canceling Headphones and Music Decrease Intraoperative Patient Anxiety During Wide-Awake Hand Surgery: A Randomized Controlled Trial. J Hand Surg Glob Online. 2021 Jun 16;3(5):254-259. doi: 10.1016/j.jhsg.2021.05.008. PMID: 35415565; PMCID: PMC8991527.
- Ilyas AM, Miller AJ, Graham JG, Matzon JL. A Prospective, Randomized, Double-Blinded Trial Comparing Acetaminophen, Ibuprofen, and Oxycodone for Pain Management After Hand Surgery. Orthopedics. 2019 Mar 1;42(2):110-115. doi: 10.3928/01477447-20190221-02. Epub 2019 Feb 27. PMID: 30810754.
- Miller A, Kim N, Ilyas AM. Prospective Evaluation of Opioid Consumption Following Hand Surgery Performed Wide Awake Versus With Sedation. Hand (N Y). 2017 Nov;12(6):606-609. doi: 10.1177/1558944716677536. Epub 2016 Nov 28. PMID: 29091490; PMCID: PMC5669329.
- Miller A, Kim N, Zmistowski B, Ilyas AM, Matzon JL. Postoperative Pain Management Following Carpal Tunnel Release: A Prospective Cohort Evaluation. Hand (N Y). 2017 Nov;12(6):541-545. doi: 10.1177/1558944716677535. Epub 2016 Nov 1. PMID: 29091486; PMCID: PMC5669328.
Minimizing Waste with Wide Awake Surgery
An ongoing issue in surgery is the high amount of waste produced harming the environment. Dr Ilyas and others have looked at this problem and have established strategies to leverage wide awake surgery as a solution to tackling this issue plaguing our society.
- Bravo D, Townsend CB, Tulipan J, Ilyas AM. Economic and Environmental Impacts of the Wide-Awake, Local Anesthesia, No Tourniquet (WALANT) Technique in Hand Surgery: A Review of the Literature. J Hand Surg Glob Online. 2022 Jun 17;4(6):456-463. doi: 10.1016/j.jhsg.2022.05.009. PMID: 36425376; PMCID: PMC9678698.
- Grothaus O, Jorgensen A, Maughan G, Anto M, Kazmers NH, Garcia BN. Carbon Footprint of Open Carpal Tunnel Release Surgery Performed in the Procedure Room Versus Operating Room Setting. J Hand Surg Am. 2024 Jun;49(6):576-582. doi: 10.1016/j.jhsa.2024.03.014. Epub 2024 May 6. PMID: 38713110.
Van Demark RE Jr, Smith VJS, Fiegen A. Lean and green hand surgery. J Hand Surg Am. 2018;43(2):179-181. https://doi.org/10.1016/j. jhsa.2017.11.007 PMID:29421068
Cost Savings with Wide Awake Surgery
Central to the establishment for wide awake surgery is the cost savings. The current paradigm for most surgeries performed in the US is payments made to the surgeon, anesthesiologist, and facility – with facility costs representing the largest and most variable portion of the financial burden. Wide wake surgery can result in tremendous cost savings to payors and patients by avoiding or mitigating the facility charges and eliminating the anesthesiologist charges.
- Rhee PC, Fischer MM, Rhee LS, McMillan H, Johnson AE. Cost Savings and Patient Experiences of a Clinic-Based, Wide-Awake Hand Surgery Program at a Military Medical Center: A Critical Analysis of the First 100 Procedures. J Hand Surg Am. 2017 Mar;42(3):e139-e147. doi: 10.1016/j.jhsa.2016.11.019. Epub 2016 Dec 20. PMID: 28011033.
- Thomas TL, Stevens CS, Goh GS, Kistler JM, Ilyas AM. Direct Variable Cost Comparison of Monitored Anesthesia Care Versus Wide Awake Local Anesthesia No Tournique Carpal Tunnel Release: A Time-Driven Activity-Based Costing Analysis. J Hand Surg Am. 2024 Sep 16:S0363-5023(24)00366-6. doi: 10.1016/j.jhsa.2024.07.021. Epub ahead of print. PMID: 39283278.
- Alter TH, Warrender WJ, Liss FE, Ilyas AM. A Cost Analysis of Carpal Tunnel Release Surgery Performed Wide Awake versus under Sedation. Plast Reconstr Surg. 2018 Dec;142(6):1532-1538. doi: 10.1097/PRS.0000000000004983. PMID: 30188472.
- Nguyen C, Milstein A, Hernandez-Boussard T, Curtin CM. The Effect of Moving Carpal Tunnel Releases Out of Hospitals on Reducing United States Health Care Charges. J Hand Surg Am. 2015 Aug;40(8):1657-62. doi: 10.1016/j.jhsa.2015.04.023. Epub 2015 Jun 9. PMID: 26070229; PMCID: PMC4516645.
- Chatterjee A, McCarthy JE, Montagne SA, Leong K, Kerrigan CL. A cost, profit, and efficiency analysis of performing carpal tunnel surgery in the operating room versus the clinic setting in the United States. Ann Plast Surg. 2011 Mar;66(3):245-8. doi: 10.1097/SAP.0b013e3181db7784. PMID: 21042185.
Building on pioneering work by Dr Don Lalonde, Dr James Clarkson’s research focused on the evidence base needed to develop an practice in the US, publishing the only national guidelines for hand surgery. This was based on the huge WALANT literature with Lalonde’s work and his own publications which include: A randomized controlled trial and a 200 patient reported outcome study. Clarkson has written a book chapter on how to deliver hand surgery in the office environment and looked at the mechanisms that VR appears to work through to reduce patient anxiety. He has also published his comparative infection rates in the main operating room and the office, where he found reduced infection rates when his patients surgical care transitioned to the office environment.